Key result
Losartan reduced blood pressure, oxidative stress, and renal injury in spontaneously hypertensive rats and DOCA-treated rats, regardless of renin status.
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Hypothesis-generating for losartan renoprotection independent of renin; clinical trials needed before human application.
Chamorro et al. (2004) studied Hypertension (animal model). Losartan vs. Control (no losartan) was evaluated on Blood pressure, ventricular hypertrophy, and renal injury. Losartan reduced blood pressure, oxidative stress, and renal injury in spontaneously hypertensive rats and DOCA-treated rats, regardless of renin status.
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