Key result
Losartan prevented the development of hypertension and cardiac and kidney hypertrophy in uninephrectomized rats with DOCA-salt hypertension.
Why the study?
Does losartan prevent hypertension, organ hypertrophy, and endothelial dysfunction in DOCA-salt and L-NAME hypertensive rats?
Does losartan prevent hypertension, organ hypertrophy, and endothelial dysfunction in DOCA-salt and L-NAME hypertensive rats?
Both NO and angiotensin II play a role in the early development of hypertension and organ hypertrophy in DOCA-salt hypertension, with losartan effectively preventing these changes.
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Animal data preclude practice change; leaves open angiotensin II blockade in early hypertension development.
-Laflamme et al. (1998) studied Deoxycorticosterone acetate-salt (DOCA) hypertension. Losartan vs. Saline was evaluated on Systolic blood pressure, cardiac and kidney hypertrophy, and mesenteric arterial bed reactivity. Losartan prevented the development of hypertension and cardiac and kidney hypertrophy in uninephrectomized rats with DOCA-salt hypertension.
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