May 28, 2005AJP Heart and Circulatory PhysiologyOpen Access

l-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats

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Why the study?

Does l-arginine attenuate cardiovascular impairment in DOCA-salt hypertensive rats?

Structured PICO

Does l-arginine attenuate cardiovascular impairment in DOCA-salt hypertensive rats?

Population

Uninephrectomized rats treated with DOCA (25 mg every 4th day sc) and 1% NaCl in the drinking water for 4 wk

Intervention

l-arginine (5% in food, 3.4 +/- 0.3 g x kg body wt(-1) x day(-1))

Comparator

Untreated DOCA-salt hypertensive rats

Outcome

Changes in cardiovascular structure and function (determined by echocardiography, microelectrode studies, histology, and studies in isolated hearts and thoracic aortic rings)surrogate

Chronic administration of l-arginine attenuates structural and functional cardiovascular impairment in a rat model of DOCA-salt hypertension.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports testing in hypertensive patients; leaves open whether benefits extend beyond this animal model.

Cite This Study

Fenning et al. (2005) studied this question.

synapsesocial.com/papers/6a751e291646b2abe503531a https://doi.org/10.1152/ajpheart.00140.2005

Topics

Echocardiography

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l-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats

Structured PICO

Discussion

Implication

Cite This Study

Topics

l-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider