In DOCA-salt hypertensive rats, calcium channel blockade with mibefradil reduces cardiovascular hypertrophy and endothelin-1 expression, whereas ACE inhibition with cilazapril has no effect.
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Suggests calcium channel blockade may offer hypertrophy benefits beyond ACE inhibition in experimental hypertension; leaves open human translation.
Jin-SLi et al. (1996) studied this question.
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