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January 1, 1996Hypertension

Vascular Structure and Expression of Endothelin-1 Gene in L-NAME–Treated Spontaneously Hypertensive Rats

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Population

Spontaneously hypertensive rats (SHR)

Comparison

Chronic administration of the L-arginine… vs Untreated spontaneously hypertensive rats (SHR)

Design

Preclinical

Follow-up

3 weeks

Authors

PSPavol SventekMedical Council of CanadaJLJin-S. LiMedical Council of CanadaKGKevin L. GroveInformation Ventures (United States)

Discussion

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Implication

Does not worsen hypertrophy despite higher BP in SHR model; leaves open NO-independent growth effects for human translation.

Structured PICO

P
Population
Spontaneously hypertensive rats (SHR)
I
Intervention
Chronic administration of the L-arginine analogue NG-nitro-L-arginine methyl ester (L-NAME) for 3 weeks
C
Comparator
Untreated spontaneously hypertensive rats (SHR)
O
Outcome
Vascular hypertrophy (aortic and mesenteric artery weights, cardiac weight, small artery media cross-sectional area) and endothelin-1 gene expression (mRNA abundance)surrogate

L-NAME-induced malignant hypertension in SHR increases vascular endothelin-1 expression but does not exacerbate cardiac or small artery hypertrophy, suggesting nitric oxide inhibition may have independent effects on cardiovascular growth.

Cite This Study

Sventek et al. (1996) studied this question.

synapsesocial.com/papers/6a7247c535aa2c282ce32ccahttps://doi.org/10.1161/01.hyp.27.1.49
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Also Consider

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