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June 1, 1997Clinical and Experimental Pharmacology and Physiology

NITRIC OXIDE SYNTHASE INHIBITION WITH Nω‐NITRO‐L‐ ARGININE METHYL ESTER AFFECTS BLOOD PRESSURE AND CARDIOVASCULAR STRUCTURE IN THE GENETICALLY HYPERTENSIVE RAT STRAIN

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Why the study?

Does nitric oxide synthase inhibition with L-NAME affect blood pressure and cardiovascular structure differently in genetically hypertensive rats compared to normotensive controls?

Population

New Zealand genetically hypertensive rat strain and normotensive control strain, starting at age 7 weeks

Comparison

N omega-nitro-L-arginine methyl ester… vs Normotensive control strain and/or untreated state

Design

Preclinical

Follow-up

3 weeks

Authors

JLJanet M. LedinghamUniversity College HospitalRLR. LavertyRidley College

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Implication

Hypertensive rat models show amplified remodeling with NOS inhibition; leaves open relevance to human hypertension mechanisms.

Structured PICO

Does nitric oxide synthase inhibition with L-NAME affect blood pressure and cardiovascular structure differently in genetically hypertensive rats compared to normotensive controls?

P
Population
New Zealand genetically hypertensive (GH) rat strain and normotensive (N) control strain, starting at age 7 weeks
I
Intervention
N omega-nitro-L-arginine methyl ester (L-NAME) administered in drinking water (10 mg/kg per day for weeks 1 and 2, then 5 mg/kg per day for week 3)
C
Comparator
Normotensive control strain and/or untreated state
O
Outcome
Blood pressure, left ventricular mass, and structure of mesenteric resistance arteries (media width, lumen diameter, media width/lumen diameter ratio)surrogate

Genetically hypertensive rats exhibit greater sensitivity to nitric oxide synthase inhibition regarding adverse cardiovascular structural remodeling compared to normotensive controls.

Cite This Study

Ledingham et al. (1997) studied this question.

synapsesocial.com/papers/6a9639cbe8ebf085abfba86bhttps://doi.org/10.1111/j.1440-1681.1997.tb01217.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased Endothelium-dependent Relaxation in New Zealand Genetic Hypertensive Rats1984 · 184 citations
  2. 2Comparison of Effect of Endothelin Antagonism and Angiotensin-Converting Enzyme Inhibition on Blood Pressure and Vascular Structure in Spontaneously Hypertensive Rats Treated WithNω-Nitro- l -Arginine Methyl Ester1996 · 36 citations
  3. 3Vascular Structure and Expression of Endothelin-1 Gene in L-NAME–Treated Spontaneously Hypertensive Rats1996 · 78 citations
  4. 4Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension1990 · 2,382 citations
  5. 5Some new, simple and efficient stereological methods and their use in pathological research and diagnosis1988 · 2,957 citations