Key result
Four-week treatment with L-NAME in male Wistar rats induced aortic remodelling that was associated with nitric oxide deficiency rather than L-NAME-induced hypertension.
Why the study?
Does L-NAME treatment induce structural remodelling of the rat aorta via NO deficiency or hypertension?
Population
Male Wistar rats
Comparison
NG-nitro-L-arginine methyl ester 20 mg/kg per… vs Control group
Design
Preclinical
Follow-up
four weeks
Authors
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Implicates nitric oxide deficiency over hypertension in L-NAME aortic remodeling; hypothesis-generating for human vascular mechanisms.
Does L-NAME treatment induce structural remodelling of the rat aorta via NO deficiency or hypertension?
Aortic remodelling in L-NAME-treated rats appears to be driven primarily by nitric oxide deficiency rather than the induced hypertension.
Bernátová et al. (1999) studied L-NAME-induced hypertension and aortic remodelling. L-NAME (NG-nitro-L-arginine methyl ester) vs. Control was evaluated on Structural and metabolic remodelling of the rat aorta. Four-week treatment with L-NAME in male Wistar rats induced aortic remodelling that was associated with nitric oxide deficiency rather than L-NAME-induced hypertension.
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