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April 1, 1999Journal of Cardiovascular Pharmacology

Long-term L-NAME treatment caused perivascular fibrosis and medial thickening despite unaltered relaxations in the small mesenteric artery and remaining constitutive NO synthase activity in the aorta.

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Population

Male Wistar-Kyoto rats

Design

Preclinical

Follow-up

8 weeks

Authors

HZHuiying ZhaoHSHiroaki ShimokawaLULemmy Uragami-Harasawa

Discussion

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Overview

L-NAME remodeling may involve NO-independent pathways; leaves open mechanisms in experimental hypertension models.

Structured PICO

P
Population
Male Wistar-Kyoto rats
I
Intervention
Oral administration of Nomega-nitro-L-arginine methyl ester (L-NAME) for 8 weeks
O
Outcome
Vascular effects including blood pressure, endothelium-dependent relaxations, NO synthase activity, and cardiovascular lesions (perivascular fibrosis and medial thickening)surrogate

The long-term cardiovascular effects of L-NAME, such as perivascular fibrosis and medial thickening, may involve mechanisms beyond the simple inhibition of endothelium-derived nitric oxide synthesis.

Cite This Study

Zhao et al. (1999) studied this question.

synapsesocial.com/papers/6a86adb3ddd5671cb07cac4ehttps://doi.org/10.1097/00005344-199904000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-Term Treatment With N ω -Nitro- l -Arginine Methyl Ester Causes Arteriosclerotic Coronary Lesions in Endothelial Nitric Oxide Synthase-Deficient Mice2002 · 86 citations
  2. 2Impairment of smooth muscle function of rat thoracic aorta in an endothelium‐independent manner by long‐term administration of NG‐nitro‐ l ‐arginine methyl ester2004 · 11 citations
  3. 3Comparison of effects of chronic and acute administration of NG‐nitro‐L‐arginine methyl ester to the rat on inhibition of nitric oxide‐mediated responses1995 · 46 citations
  4. 4Chronic-low-dose L-NAME treatment increases nitric oxide production and vasorelaxation in normotensive rats2007 · 23 citations
  5. 5Overall Hemodynamic Studies After the Chronic Inhibition of Endothelial-Derived Nitric Oxide in Rats1995 · 31 citations