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January 1, 2007Physiological ResearchOpen Access

Chronic low-dose L-NAME treatment significantly elevated NO synthase activity in the left ventricle and aorta, increased endothelium-dependent acetylcholine-induced vasorelaxation, and reduced serotonin-induced vasoconstriction of the femoral artery.

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Why the study?

Does chronic low-dose L-NAME treatment affect NO production and vasorelaxation in normotensive rats?

Population

Adult male Wistar rats (normotensive)

Comparison

L-NAME approximately 1.5 mg/kg/day in drinking… vs Control rats

Design

Preclinical

Follow-up

8 weeks

Authors

IBIveta BernátováJKJana KopincováAPAngelika Púzserová

Discussion

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Overview

Caution against clinical translation of low-dose L-NAME; leaves open paradoxical NO enhancement mechanisms in normotensive models.

Structured PICO

Does chronic low-dose L-NAME treatment affect NO production and vasorelaxation in normotensive rats?

P
Population
Adult male Wistar rats (normotensive)
I
Intervention
L-NAME approximately 1.5 mg/kg/day in drinking water for 8 weeks
C
Comparator
Control rats
O
Outcome
Nitric oxide (NO) production, vascular function, and structure of the heart and selected arteriessurrogate

Chronic low-dose L-NAME treatment paradoxically increases NO production and vasorelaxation in normotensive rats without causing adverse cardiovascular structural changes.

Cite This Study

Bernátová et al. (2007) studied this question.

synapsesocial.com/papers/6a88ead13aa2d8278f75fefdhttps://doi.org/10.33549/physiolres.931393
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Also Consider

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  1. 1Long-Term Vascular Effects of Nω-Nitro-L-Arginine Methyl Ester are Not Solely Mediated by Inhibition of Endothelial Nitric Oxide Synthesis in the Rat Mesenteric Artery1999 · 18 citations
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  3. 3Impairment of smooth muscle function of rat thoracic aorta in an endothelium‐independent manner by long‐term administration of NG‐nitro‐ l ‐arginine methyl ester2004 · 11 citations
  4. 4Mechanism of Structural Remodelling of the Rat Aorta During Long-Term NG-Nitro-L-arginine Methyl Ester Treatment1999 · 15 citations
  5. 5Overall Hemodynamic Studies After the Chronic Inhibition of Endothelial-Derived Nitric Oxide in Rats1995 · 32 citations