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December 28, 2002Cardiovascular ResearchOpen Access

Discoordinate re-expression of cardiac fetal genes in Nω-nitro-?-arginine methyl ester (?-NAME) hypertension

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Population

Male Sprague-Dawley rats (n=24)

Comparison

N-nitro-L-arginine methyl ester 75 mg/kg/day for… vs Untreated rats

Design

Preclinical

Follow-up

4 or 8 weeks

Authors

YZYingao ZhangCedars-Sinai Medical Center

Discussion

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Overview

Beta-MHC may mark pressure overload without hypertrophy in rats; leaves open fetal gene dissociation in human hypertensive remodeling.

Structured PICO

P
Population
Male Sprague-Dawley rats (n=24)
I
Intervention
N(omega)-nitro-L-arginine methyl ester (L-NAME) 75 mg/kg/day for 4 or 8 weeks
C
Comparator
Untreated rats
O
Outcome
Transcriptional activation of cardiac fetal genes (ANF, BNP, beta-MHC) and cardiac renin/ACE activitysurrogate

In a rat model of L-NAME-induced hypertension, increased beta-MHC expression serves as a marker of LV pressure overload even in the absence of LV hypertrophy, indicating a disruption in the coordinated transcriptional activation of cardiac fetal genes.

Cite This Study

Yingao Zhang (2002) studied this question.

synapsesocial.com/papers/6a86adb3ddd5671cb07cac47https://doi.org/10.1016/s0008-6363(02)00654-5

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac weight in hypertension induced by nitric oxide synthase blockade.1993 · 183 citations
  2. 2Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase.1992 · 260 citations
  3. 3Comparison of Effect of Endothelin Antagonism and Angiotensin-Converting Enzyme Inhibition on Blood Pressure and Vascular Structure in Spontaneously Hypertensive Rats Treated WithNω-Nitro- l -Arginine Methyl Ester1996 · 36 citations
  4. 4Evidence for Load-Dependent and Load-Independent Determinants of Cardiac Natriuretic Peptide Production1996 · 125 citations
  5. 5Long-term nitric oxide synthase inhibition and distensibility of carotid artery in intact rats.1994 · 47 citations