Why the study?
Does cilazapril or bosentan reduce blood pressure and vascular hypertrophy in spontaneously hypertensive rats treated with L-NAME?
Population
Spontaneously hypertensive rats (SHR) treated chronically with L-NAME (SHR-L-NAME)
Comparison
Cilazapril or bosentan for 3 weeks vs Untreated SHR-L-NAME
Design
Preclinical
Follow-up
3 weeks
Authors
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ACE inhibition but not endothelin antagonism attenuates vascular hypertrophy in L-NAME rats; leaves open clinical relevance in human malignant hypertension.
Does cilazapril or bosentan reduce blood pressure and vascular hypertrophy in spontaneously hypertensive rats treated with L-NAME?
In a rat model of malignant hypertension induced by L-NAME, ACE inhibition but not endothelin antagonism lowered blood pressure and reduced vascular hypertrophy, suggesting a key role for the renin-angiotensin system.
Li et al. (1996) studied this question.
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