March 1, 1997Hypertension

Blood Pressure and Vascular Effects of Endothelin Blockade in Chronic Nitric Oxide–Deficient Hypertension

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Why the study?

Does bosentan improve blood pressure and vascular function in rats with L-NAME-induced hypertension?

Structured PICO

Does bosentan improve blood pressure and vascular function in rats with L-NAME-induced hypertension?

Population

Six-week-old Wistar-Kyoto rats with N(omega)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension

Intervention

Bosentan (100 mg/kg per day) added to L-NAME (70 mg/kg per day) for 6 weeks

Comparator

Placebo (control) or L-NAME alone (70 mg/kg per day)

Outcome

Blood pressure, vascular function and structure of small arteries, and reactivity of the aortasurrogate

Endothelin blockade with bosentan plays a minor role in preventing chronic L-NAME-induced hypertension and concomitant vascular structural alterations in rats.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Bosentan ineffective in L-NAME rat hypertension; leaves open endothelin blockade role in other models or humans.

Cite This Study

Moreau et al. (1997) studied this question.

synapsesocial.com/papers/6a82442d2beaf6c72d877d00 https://doi.org/10.1161/01.hyp.29.3.763

Topics

Hypertension management

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Blood Pressure and Vascular Effects of Endothelin Blockade in Chronic Nitric Oxide–Deficient Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Topics

Blood Pressure and Vascular Effects of Endothelin Blockade in Chronic Nitric Oxide–Deficient Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider