Population
16 spontaneously hypertensive rats (SHR) with streptozotocin-induced diabetes (2 groups of n=8)
Comparison
NG-nitro-L-arginine methyl ester 5 mg/kg… vs Daily subcutaneous injections of Ultratard insulin
Design
Preclinical
Follow-up
8 weeks
Authors
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Hypothesis-generating in diabetic hypertensive rats; leaves open translation to human proteinuria management.
Nitric oxide synthase inhibition exacerbates proteinuria and hypertension in a diabetic hypertensive rat model, likely via renin-angiotensin system activation.
Wessels et al. (1997) studied this question.
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