Key result
Induction of diabetes in rats treated with L-NAME caused a progressive increase in mean arterial pressure averaging approximately 70 mmHg greater than in vehicle-treated diabetic rats.
Why the study?
Does nitric oxide synthesis inhibition with L-NAME exacerbate hypertension at the onset of streptozotocin-induced diabetes in rats?
Population
Rats (n=22 total)
Comparison
N-nitro-L-arginine methyl ester 10 microg.kg.min… vs Vehicle-treated diabetic rats and nondiabetic…
Design
Preclinical
Follow-up
3 weeks post-diabetes induction
Authors
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Potential protective role of nitric oxide against early diabetic hypertension is hypothesis-generating; leaves open translation to human disease.
Does nitric oxide synthesis inhibition with L-NAME exacerbate hypertension at the onset of streptozotocin-induced diabetes in rats?
Mean Difference: 70
In the early stages of diabetes, nitric oxide synthesis appears crucial to prevent the development of hypertension, potentially by maintaining glomerular filtration and suppressing renin secretion.
Fitzgerald et al. (2000) studied Diabetes and hypertension (n=22). N(G)-nitro-L-arginine methyl ester (L-NAME) vs. Vehicle was evaluated on Mean arterial pressure (MD 70 mmHg). Induction of diabetes in rats treated with L-NAME caused a progressive increase in mean arterial pressure averaging approximately 70 mmHg greater than in vehicle-treated diabetic rats.
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