Why the study?
Does nitric oxide modulation with L-NAME or GTN alter renal hemodynamics and urinary NO2/NO3 excretion in streptozocin-induced diabetic rats?
Population
Conscious streptozocin-induced diabetic (D) and age-matched control (C) rats
Comparison
Intravenous bolus of low-dose L-NAME, high-dose… vs Age-matched control rats receiving the same…
Design
Preclinical
Authors
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Indicates impaired NO responsiveness in diabetic kidneys; leaves open whether NO modulation affects hyperfiltration in patients.
Does nitric oxide modulation with L-NAME or GTN alter renal hemodynamics and urinary NO2/NO3 excretion in streptozocin-induced diabetic rats?
Increased renal production and/or sensitivity to endothelium-derived relaxing factor/NO may play a role in the genesis of diabetic hyperfiltration.
Komers et al. (1994) studied this question.
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