Why the study?
Does NO synthase inhibition with L-NAME normalize renal hemodynamic responses to reduced perfusion pressure in diabetic rats?
Population
Anesthetized Munich-Wistar rats with 6 weeks of streptozotocin-induced, insulin-treated diabetes, and…
Comparison
Intrarenal arterial infusion of NO synthase… vs Before infusion and nondiabetic littermates
Design
Preclinical
Authors
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NO contributes to diabetic rat renal hyperfiltration; leaves open relevance to human diabetic kidney disease.
Does NO synthase inhibition with L-NAME normalize renal hemodynamic responses to reduced perfusion pressure in diabetic rats?
Increased endogenous NO activity contributes to basal hyperfiltration and persistent renal vasodilation at reduced perfusion pressures in diabetic rats.
Tolins et al. (1993) studied this question.
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