Population
Early streptozotocin (STZ)-diabetic rats and healthy control rats
Comparison
L-NAME iv, acetylcholine, and combined… vs Healthy control rats
Design
Preclinical
Authors
Loading...
Preserved NO tone in early STZ-diabetes challenges assumptions of early endothelial dysfunction; leaves open translation to human vasculopathy.
The study demonstrates that basal vasodilating nitric oxide tone and sensitivity to acetylcholine are not impaired in the early stages of streptozotocin-induced diabetes in rats.
Granstam et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: