Why the study?
Does L-NAME alter local cerebral blood flow in spontaneously diabetic insulin-dependent BioBred rats compared to non-diabetic controls?
Population
Spontaneously diabetic insulin-dependent BioBred (BB) rats and non-diabetic controls
Comparison
NG-nitro-L-arginine methyl ester 30 mg kg-1… vs Saline
Design
Preclinical
Follow-up
20 minutes
Authors
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Attenuated LCBF response in diabetic rats suggests endothelial dysfunction; hypothesis-generating for cerebrovascular complications and requires human validation.
Does L-NAME alter local cerebral blood flow in spontaneously diabetic insulin-dependent BioBred rats compared to non-diabetic controls?
Spontaneously diabetic rats exhibit an attenuated cerebrovascular response to NOS inhibition, suggesting endothelial dysfunction and loss of NO-induced dilator tone.
Fouyas et al. (1996) studied this question.
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