Why the study?
Does chronic L-NAME treatment alter mean arterial pressure and vascular reactivity differently in spontaneously diabetic BB/E rats compared to non-diabetic rats?
Population
Spontaneously diabetic, insulin-dependent BB/Edinburgh rats and age-matched non-diabetic controls.
Comparison
Chronic in vivo administration of L-NAME from 30… vs Untreated non-diabetic rats, untreated diabetic…
Design
Preclinical
Follow-up
123 days (from 30 to 153 days of age)
Authors
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Attenuated hypertension with L-NAME in diabetic rats should not alter clinical NO inhibition strategies; leaves open vascular NO adaptations in experimental diabetes.
Does chronic L-NAME treatment alter mean arterial pressure and vascular reactivity differently in spontaneously diabetic BB/E rats compared to non-diabetic rats?
In spontaneously diabetic BB/E rats, chronic NO synthase inhibition with L-NAME results in attenuated hypertension and absent enhanced vascular responsiveness to noradrenaline, suggesting functional changes in NO synthesis and metabolism in diabetes.
Lindsey et al. (1997) studied this question.
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