January 1, 2000Journal of Diabetes ResearchOpen Access

Alterations in Nitric Oxide Activity and Sensitivity in Early Streptozotocin‐Induced Diabetes Depend on Arteriolar Size

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Why the study?

Does streptozotocin-induced diabetes alter nitric oxide activity and sensitivity in different sizes of arterioles in rats?

Population

Male Wistar rats with 6 weeks' streptozotocin-induced diabetes (n=6) and age-matched untreated controls (n=8)

Comparison

Topical application of acetylcholine… vs Age-matched untreated control rats (n=8)

Design

Preclinical

Follow-up

6 weeks

Authors

BVBastiaan vanDam CDCihan DemirciApple (Israel)HRHans J. Reitsma

Discussion

Member takes

Implication

Size-dependent NO changes in diabetic rat arterioles are hypothesis-generating; human studies needed before any clinical relevance.

Structured PICO

Does streptozotocin-induced diabetes alter nitric oxide activity and sensitivity in different sizes of arterioles in rats?

Population

Male Wistar rats with 6 weeks' streptozotocin-induced diabetes (n=6) and age-matched untreated controls (n=8)

Intervention

Topical application of acetylcholine, nitroprusside, and N(G)-nitro-L-arginine (L-NNA) to the in situ spinotrapezius muscle preparation

Comparator

Age-matched untreated control rats (n=8)

Outcome

Basal inside diameters of A2-A4 arterioles and reactivity to topically applied acetylcholine and nitroprusside, before and after L-NNAsurrogate

Early streptozotocin-induced diabetes in rats causes anatomically specific alterations in microvascular nitric oxide activity and sensitivity that depend on arteriolar size.

Limitations

Experimental setup did not allow for a complete dose-response relationship of acetylcholine
Cannot exclude that diameter differences are partly caused by changes in production of other vasorelaxing or constricting agents
Exact mechanism of STZ-induced changes in arteriolar reactivity is beyond the scope of the study

Cite This Study

vanDam et al. (2000) studied this question.

synapsesocial.com/papers/6a89100a789d3eba981a2acd https://doi.org/10.1155/edr.2000.221

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Alterations in Nitric Oxide Activity and Sensitivity in Early Streptozotocin‐Induced Diabetes Depend on Arteriolar Size

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Alterations in Nitric Oxide Activity and Sensitivity in Early Streptozotocin‐Induced Diabetes Depend on Arteriolar Size

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider