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June 1, 1995AJP Heart and Circulatory Physiology

Effects of chronic NO synthase inhibition in rats on renin-angiotensin system and sympathetic nervous system

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Population

Rats kept on a normal (RS) or a low-sodium (LS) diet

Design

Preclinical

Follow-up

6 weeks

Authors

AZAnne ZanchiNSNicolas SchaadMOM. C. Osterheld

Discussion

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Overview

Highlights dual sympathetic-RAS involvement in experimental NOS-inhibition hypertension; leaves open translation to human therapy.

Structured PICO

P
Population
Rats kept on a normal (RS) or a low-sodium (LS) diet
I
Intervention
NG-nitro-L-arginine methyl ester (L-NAME) in drinking water (0.4 milligrams) for 6 weeks, followed by losartan (10 mg/kg) and phentolamine (0.1 mg/kg) intravenous bolus injections
O
Outcome
Mean intra-arterial blood pressuresurrogate

Hypertension induced by chronic NOS inhibition in rats is sustained by the activation of both the sympathetic nervous system and the renin-angiotensin system.

Cite This Study

Zanchi et al. (1995) studied this question.

synapsesocial.com/papers/6a7dbac0d0946debe9150243https://doi.org/10.1152/ajpheart.1995.268.6.h2267
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sodium Sensitivity And Sympathetic Nervous System In Hypertension Induced By Long‐Term Nitric Oxide Blockade In Rats2000 · 15 citations
  2. 2Chronic nitric oxide inhibition with <scp>l</scp>-NAME: effects on autonomic control of the cardiovascular system1998 · 71 citations
  3. 3Sympathetic functions in NG-nitro-L-arginine-methylester-induced hypertension1998 · 29 citations
  4. 4Hormonal, renal, and metabolic alterations during hypertension induced by chronic inhibition of NO in rats1994 · 72 citations
  5. 5Salt‐Sensitive Hypertension Resulting From Nitric Oxide Synthase Inhibition is Associated with Loss of Regulation of Angiotensin II in the Rat2002 · 28 citations