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January 1, 1998Journal of Hypertension

Sympathetic functions in NG-nitro-L-arginine-methylester-induced hypertension

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Population

Rats (conscious rats and isolated atria)

Comparison

NG-nitro-L-arginine-methyl-ester for 40 days… vs Sham-treated rats

Design

Preclinical

Follow-up

40 days

Authors

ALAnnik K. LaflammeSFSylvain FoucartPMPierre Moreau

Discussion

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Overview

Highlights AT1-cAMP interactions in nitric oxide-deficient hypertension; leaves open translation to clinical practice.

Structured PICO

P
Population
Rats (conscious rats and isolated atria)
I
Intervention
NG-nitro-L-arginine-methyl-ester (L-NAME) for 40 days, with or without losartan or enalaprilat treatment during the last 12 days
C
Comparator
Sham-treated rats
O
Outcome
Haemodynamic parameters, release of noradrenaline, and cardiac beta-adrenergic-adenylyl cyclase pathway activitysurrogate

In a rat model of L-NAME-induced hypertension, nitric oxide plays a modulatory role in cAMP formation, to which angiotensin II contributes via an AT1 receptor-mediated mechanism.

Cite This Study

Laflamme et al. (1998) studied this question.

synapsesocial.com/papers/6a70637ee5469ee92be11ff2https://doi.org/10.1097/00004872-199816010-00011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase.1992 · 260 citations
  2. 2Evidence that the Autonomic Nervous System Plays a Major Role in the L-NAME - Induced Hypertension in Conscious Rats1993 · 98 citations
  3. 3Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition.1993 · 200 citations
  4. 4Decreased cardiac baroreflex sensitivity is not due to cardiac hypertrophy in NG-nitro-L-arginine methyl ester-induced hypertension1994 · 36 citations
  5. 5Role of endothelium-derived nitric oxide in the regulation of blood pressure.1989 · 1,838 citations