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June 1, 1993HypertensionOpen Access

Sodium and angiotensin in hypertension induced by long-term nitric oxide blockade.

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Why the study?

Does dietary sodium restriction or losartan prevent hypertension induced by long-term nitric oxide blockade in Wistar rats?

Population

Wistar rats with hypertension induced by a 25-day period of administration of the inhibitor of nitric oxide…

Comparison

Dietary sodium restriction or losartan… vs Normal sodium diet and corresponding controls…

Design

Preclinical

Follow-up

25 days

Authors

BJBernard JoverCentre National de la Recherche ScientifiqueAHAbderraouf HériziUniversité de MontpellierFVF VentreCentre Hospitalier Universitaire de Montpellier

Discussion

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Implication

Does not support clinical adoption or sodium restriction; leaves open whether RAS blockade translates to human nitric oxide-deficient hypertension.

Structured PICO

Does dietary sodium restriction or losartan prevent hypertension induced by long-term nitric oxide blockade in Wistar rats?

P
Population
Wistar rats with hypertension induced by a 25-day period of administration of the inhibitor of nitric oxide synthesis NG-nitro-L-arginine-methyl ester (10 mg/kg twice daily by gavage)
I
Intervention
Dietary sodium restriction (low sodium diet) or losartan (30 mg/kg once daily by gavage) administered before and during NG-nitro-L-arginine-methyl ester
C
Comparator
Normal sodium diet and corresponding controls without losartan
O
Outcome
Conscious systolic arterial pressuresurrogate

In a rat model of hypertension induced by long-term nitric oxide blockade, the renin-angiotensin system plays a crucial role as demonstrated by the preventive effect of losartan, while dietary sodium restriction has no effect.

Cite This Study

Jover et al. (1993) studied this question.

synapsesocial.com/papers/6a71e770660549caf2c655dfhttps://doi.org/10.1161/01.hyp.21.6.944
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase.1992 · 260 citations
  2. 2Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage.1992 · 735 citations
  3. 3NG-monomethyl-L-arginine and nitroarginine potentiate pressor responsiveness of vasoconstrictors in conscious rats1992 · 61 citations
  4. 4Endothelium-derived relaxing factor regulates renin release in vivo1992 · 90 citations
  5. 5Inhibition of nitric oxide, bradykinin, and prostaglandins in normal rats.1992 · 34 citations