Key result
Chronic oral administration of nitro-L-arginine for 4-6 weeks in rats induced severe arterial hypertension, with tail-cuff pressure reaching 164 +/- 6 mm Hg compared to 108 +/- 3 mm Hg in controls.
Why the study?
Does chronic nitric oxide blockade with nitro-L-arginine induce arterial hypertension and renal vasoconstriction in Munich-Wistar rats?
Population
Munich-Wistar rats
Comparison
Oral nitro-L-arginine for 4-6 weeks vs Age-matched untreated rats
Design
Preclinical
Follow-up
4-6 weeks
Authors
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Caution against human extrapolation; extends experimental models of nitric oxide deficiency in hypertension.
Does chronic nitric oxide blockade with nitro-L-arginine induce arterial hypertension and renal vasoconstriction in Munich-Wistar rats?
Absolute Event Rate: 164% vs 108%
Chronic nitric oxide blockade with nitro-L-arginine in rats creates a new model of severe arterial hypertension characterized by marked renal vasoconstriction and hypoperfusion.
Ribeiro et al. (1992) studied Arterial hypertension. nitro-L-arginine vs. untreated controls was evaluated on Tail-cuff pressure. Chronic oral administration of nitro-L-arginine for 4-6 weeks in rats induced severe arterial hypertension, with tail-cuff pressure reaching 164 +/- 6 mm Hg compared to 108 +/- 3 mm Hg in controls.
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