Key result
Inhibition of nitric oxide production in dogs with renovascular hypertension elicited more severe hypertension, accompanied by lower plasma renin activity and angiotensin II concentrations.
Why the study?
Does nitric oxide modulation alter hemodynamics and the renin-angiotensin system in dogs with renovascular hypertension?
Does nitric oxide modulation alter hemodynamics and the renin-angiotensin system in dogs with renovascular hypertension?
Nitric oxide plays an important role in modulating the peripheral renin-angiotensin system and buffering the increase in vascular resistance during the evolution of renovascular hypertension.
No takes yet. Share an insight, caveat, or question.
NO inhibition worsens renovascular hypertension in dogs with suppressed RAS; hypothesis-generating for human NO-RAS interactions.
Nakamoto et al. (1995) studied Renovascular hypertension. N ω -nitro- l -arginine or l -arginine vs. Placebo was evaluated on Hemodynamic and hormonal effects (blood pressure, plasma renin activity, angiotensin II concentrations). Inhibition of nitric oxide production in dogs with renovascular hypertension elicited more severe hypertension, accompanied by lower plasma renin activity and angiotensin II concentrations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: