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January 1, 2000Acta Physiologica Scandinavica

Nitric oxide–angiotensin II interactions in angiotensin II‐dependent hypertension

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Why the study?

Does inhibition of nitric oxide synthesis affect renal hemodynamics differently in ANG II-infused hypertensive rats compared to control rats?

Population

ANG II-infused hypertensive rat model

Comparison

Inhibition of nitric oxide synthesis (NOS) vs Control rats

Design

Preclinical

Authors

NNavarIIchiharaCChin

Discussion

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Overview

Highlights renoprotective cortical eNOS in early ANG II hypertension; hypothesis-generating for human renal hemodynamics.

Structured PICO

Does inhibition of nitric oxide synthesis affect renal hemodynamics differently in ANG II-infused hypertensive rats compared to control rats?

P
Population
ANG II-infused hypertensive rat model
I
Intervention
Inhibition of nitric oxide synthesis (NOS)
C
Comparator
Control rats
O
Outcome
Renal blood flow and glomerular filtration ratesurrogate

Cortical Ca2+-dependent NOS (primarily endothelial NOS) is stimulated during early ANG II-induced hypertension and exerts a renoprotective effect on cortical hemodynamics.

Cite This Study

Navar et al. (2000) studied this question.

synapsesocial.com/papers/6a7160eb439bab0cabc38e29https://doi.org/10.1046/j.1365-201x.2000.00630.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II Stimulates Synthesis of Endothelial Nitric Oxide Synthase1998 · 104 citations
  2. 2Neuronal Nitric Oxide Synthase-Dependent Afferent Arteriolar Function in Angiotensin II-Induced Hypertension1999 · 28 citations
  3. 3Role of nitric oxide in modulating the chronic renal and arterial pressure responses to angiotensin II1997 · 7 citations
  4. 4Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells1998 · 213 citations
  5. 5Immunohistochemically Detected Protein Nitration Indicates Sites of Renal Nitric Oxide Release in Goldblatt Hypertension1997 · 66 citations