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August 1, 2001HypertensionOpen Access

Role of nNOS in Regulation of Renal Function in Angiotensin II–Induced Hypertension

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Why the study?

Does intrarenal nNOS inhibition alter renal function in normotensive and Angiotensin II-induced hypertensive rats?

Population

Wistar rats infused with either saline or Angiotensin II by subcutaneously implanted osmotic minipumps

Comparison

Acute intrarenal administration of the nNOS… vs Intrarenal infusion of saline (SAL)

Design

Preclinical

Follow-up

13 days after implantation

Authors

LČLuděk ČervenkaCross-Cutting CardiologyHKHerbert J. KramerUniversity of SienaJMJan MalýUniversity Hospital Hradec Králové

Discussion

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Implication

No immediate clinical implications for hypertension; leaves open nNOS impairment as a mechanism in human disease.

Structured PICO

Does intrarenal nNOS inhibition alter renal function in normotensive and Angiotensin II-induced hypertensive rats?

P
Population
Wistar rats infused with either saline (SAL, n=28) or Angiotensin II (80 ng/min, n=30) by subcutaneously implanted osmotic minipumps
I
Intervention
Acute intrarenal administration of the nNOS inhibitor S-methyl-L-thiocitrulline (L-SMTC; 0.3 mg/h), with or without pretreatment by AT(1) receptor antagonist candesartan (750 ng IR)
C
Comparator
Intrarenal infusion of saline (SAL)
O
Outcome
In vivo renal functional responses (glomerular filtration rate, renal plasma flow, and absolute sodium excretion)surrogate

In normotensive rats, nNOS-derived NO counteracts Ang II-mediated vasoconstriction, whereas Ang II-infused hypertensive rats exhibit an impaired ability to release NO by nNOS, which may contribute to the maintenance of hypertension.

Cite This Study

Červenka et al. (2001) studied this question.

synapsesocial.com/papers/6a75a4f8d17bc701ee161455https://doi.org/10.1161/01.hyp.38.2.280
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Also Consider

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