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January 1, 1999Hypertension

Neuronal Nitric Oxide Synthase-Dependent Afferent Arteriolar Function in Angiotensin II-Induced Hypertension

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Population

Sprague-Dawley rats (n=47 total: 23 control, 24 Ang II-infused)

Comparison

Angiotensin II 60 ng/min subcutaneously for 13… vs Control rats without Angiotensin II infusion

Design

Preclinical

Follow-up

13 days

Authors

AIAtsuhiro IchiharaGeneral / Preventive / LipidsJIJohn D. ImigVascular MedicineLNL. Gabriel NavarVascular Medicine

Discussion

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Overview

Suggests Ang II impairs nNOS buffering of afferent tone in rats; leaves open relevance to human hypertension.

Structured PICO

P
Population
Sprague-Dawley rats (n=47 total: 23 control, 24 Ang II-infused)
I
Intervention
Angiotensin II 60 ng/min subcutaneously for 13 days, followed by in vitro assessment of afferent arteriolar responses to nNOS inhibitor S-methyl-L-thiocitrulline (L-SMTC) and nonselective NOS inhibitor Nomega-nitro-L-arginine (L-NNA)
C
Comparator
Control rats without Angiotensin II infusion
O
Outcome
Afferent arteriolar diameter response to L-SMTC and L-NNAsurrogate

Chronic Angiotensin II infusion impairs the ability of nNOS-derived nitric oxide to buffer afferent arteriolar constriction in response to increased distal tubular flow.

Cite This Study

Ichihara et al. (1999) studied this question.

synapsesocial.com/papers/6a855dd1beaf5c5b09108e55https://doi.org/10.1161/01.hyp.33.1.462

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neuronal nitric oxide synthase modulates rat renal microvascular function1998 · 132 citations
  2. 2Renoprotective effects of nitric oxide in angiotensin II-induced hypertension in the rat1998 · 74 citations
  3. 3Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.1993 · 196 citations
  4. 4Modulation of Tubuloglomerular Feedback by Angiotensin II Type 1 Receptors During the Development of Goldblatt Hypertension1995 · 70 citations
  5. 5Upregulation of Renal and Vascular Nitric Oxide Synthase in Young Spontaneously Hypertensive Rats1998 · 243 citations