Key result
In rats, 1-week treatment with the nNOS inhibitor 7-NI reduced the renal blood flow decrease in response to Angiotensin II compared to controls (23 +/- 8% vs. 60 +/- 11%).
Why the study?
Does chronic inhibition of nNOS with 7-NI alter the renal vascular response to angiotensin II in rats?
Population
Rats (two control groups and two groups treated with nNOS inhibitor)
Comparison
7-nitro indazole for 1 and 4 weeks, followed by… vs Control rats
Design
Preclinical
Follow-up
4 weeks
Authors
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Chronic nNOS inhibition may blunt renal Ang II reactivity in rats; hypothesis-generating and requires translational validation before clinical relevance.
Does chronic inhibition of nNOS with 7-NI alter the renal vascular response to angiotensin II in rats?
Absolute Event Rate: 23% vs 60%
Chronic blockade of nNOS for 1 week diminishes the renal blood flow and cytosolic calcium response to Angiotensin II in rats.
Ollerstam et al. (2002) studied Renal vascular response. 7-nitro indazole (7-NI) vs. Control was evaluated on Decrease in renal blood flow (RBF) after bolus Angiotensin II. In rats, 1-week treatment with the nNOS inhibitor 7-NI reduced the renal blood flow decrease in response to Angiotensin II compared to controls (23 +/- 8% vs. 60 +/- 11%).
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