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May 1, 1998AJP Renal Physiology

Renoprotective effects of nitric oxide in angiotensin II-induced hypertension in the rat

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Why the study?

Does acute NO synthase inhibition affect renal cortical and medullary blood flow differently in ANG II-induced hypertensive rats compared to normotensive rats?

Population

Anesthetized male Sprague-Dawley rats, n=15

Comparison

Intravenous infusion of N omega-nitro-L-arginine vs Normotensive control rats receiving the same NLA…

Design

Preclinical

Follow-up

Acute (during infusion)

Authors

SCSo Yeon ChinCWChi-Tarng WangDMDewan S. A. Majid

Discussion

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Overview

Indicates compensatory NO activity helps preserve cortical perfusion in ANG II hypertension; leaves open clinical translation or therapeutic targeting.

Structured PICO

Does acute NO synthase inhibition affect renal cortical and medullary blood flow differently in ANG II-induced hypertensive rats compared to normotensive rats?

P
Population
Anesthetized male Sprague-Dawley rats, n=15 (8 normotensive controls, 7 ANG II-infused hypertensive rats prepared by infusion of ANG II at 65 ng/min via osmotic minipumps for 13 days)
I
Intervention
Intravenous infusion of N omega-nitro-L-arginine (NLA; 20 micrograms.100 g-1.min-1)
C
Comparator
Normotensive control rats receiving the same NLA infusion
O
Outcome
Renal cortical blood flow (CBF) and medullary blood flow (MBF) measured by laser-Doppler flow probessurrogate

A compensatory increase in nitric oxide activity partially counteracts the vasoconstrictor influence of elevated ANG II levels to regulate renal hemodynamics and maintain cortical perfusion in rats.

Cite This Study

Chin et al. (1998) studied this question.

synapsesocial.com/papers/6a751e291646b2abe5035323https://doi.org/10.1152/ajprenal.1998.274.5.f876
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric oxide–angiotensin II interactions in angiotensin II‐dependent hypertension2000 · 64 citations
  2. 2Role of nNOS in Regulation of Renal Function in Angiotensin II–Induced Hypertension2001 · 33 citations
  3. 3Protective Effect of Angiotensin II-Induced Increase in Nitric Oxide in the Renal Medullary Circulation1998 · 151 citations
  4. 4Interactions Between Nitric Oxide and Angiotensin II on Renal Cortical and Papillary Blood Flow1997 · 31 citations
  5. 5Interactive Nitric Oxide–Angiotensin II Influences on Renal Microcirculation in Angiotensin II–Induced Hypertension1998 · 47 citations