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March 1, 1996AJP Regulatory Integrative and Comparative Physiology

Nitric oxide modulates angiotensin II- and norepinephrine-dependent vasoconstriction in rat kidney

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Why the study?

Does nitric oxide modulation affect angiotensin II- and norepinephrine-dependent renal vasoconstriction in anesthetized rats?

Population

Anesthetized rats

Comparison

Nitric oxide modulation during angiotensin II or… vs Angiotensin II or norepinephrine infusion alone

Design

Preclinical

Authors

NPN. ParekhLDLeszek DobrowolskiAZA. P. Zou

Discussion

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Overview

NO attenuates renal vasoconstrictor responses in rat models; leaves open translation to human cardiorenal hemodynamics.

Key Points

  • To determine how varying levels of nitric oxide modulate angiotensin II- and norepinephrine-induced renal vasoconstriction in anesthetized rats.
  • Infused angiotensin II or norepinephrine intravenously in anesthetized rats before and after systemic nitric oxide synthase inhibition with nitro-L-arginine methyl ester (L-NAME).
  • Infused vasoconstrictors, the nitric oxide donor sodium nitroprusside (SNP), and L-NAME directly into the renal artery to isolate local vascular responses from systemic extrarenal effects.
  • Systemic L-NAME enhanced intravenous angiotensin II-mediated renal blood flow reduction from 26% to 49% without altering norepinephrine-induced reductions, with neither drug affecting medullary blood flow.
  • Intra-arterial sodium nitroprusside attenuated renal blood flow reduction by both agonists to 60% of control, intra-arterial L-NAME enhanced reduction to 200% of control, and combined L-NAME plus sodium nitroprusside normalized reduction to 90% of control.

Structured PICO

Does nitric oxide modulation affect angiotensin II- and norepinephrine-dependent renal vasoconstriction in anesthetized rats?

P
Population
Anesthetized rats
I
Intervention
Nitric oxide modulation (L-NAME to decrease NO, sodium nitroprusside [SNP] to increase NO, or L-NAME + SNP to restore NO) during angiotensin II or norepinephrine infusion
C
Comparator
Angiotensin II or norepinephrine infusion alone
O
Outcome
Changes in renal blood flow (RBF) and medullary blood flowsurrogate

Nitric oxide attenuates renal vasoconstriction induced by angiotensin II and norepinephrine, and this antagonism is not due to constrictor-induced NO production.

Cite This Study

Parekh et al. (1996) studied this question.

synapsesocial.com/papers/6a8c2f4ef19228bbb2fb76aehttps://doi.org/10.1152/ajpregu.1996.270.3.r630
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Basally Synthesized Nitric Oxide in Modulating the Renal Vasoconstrictor Action of Angiotensin II.1997 · 8 citations
  2. 2Interactions Between Nitric Oxide and Angiotensin II on Renal Cortical and Papillary Blood Flow1997 · 31 citations
  3. 3Basal nitric oxide production curtails arteriolar vasoconstrictor responses to ANG II in rat kidney1996 · 51 citations
  4. 4Enhancement of Norepinephrine and Angiotensin II-Induced Renal Effects by NG-Nitro-L-arginine, a Nitric Oxide Synthase Inhibitor.1995 · 13 citations
  5. 5Regional Blood Flow Responses to Acute ANG II Infusion: Effects of Nitric Oxide Synthase Inhibition1999 · 17 citations