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January 1, 1995Biological and Pharmaceutical BulletinOpen Access

Enhancement of Norepinephrine and Angiotensin II-Induced Renal Effects by NG-Nitro-L-arginine, a Nitric Oxide Synthase Inhibitor.

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Why the study?

Does NG-nitro-L-arginine enhance norepinephrine- and angiotensin II-induced renal vasoconstriction and antidiuresis in anesthetized dogs?

Population

Anesthetized dogs

Comparison

Intrarenal administration of a NO synthase… vs Norepinephrine or angiotensin II infusion alone…

Design

Preclinical

Authors

YMY MatsumuraNational Cancer Center Hospital EastYEYasuhiro EgiMitsubishi Tanabe Pharma CorporationSMS MurataKyoto Pharmaceutical University

Discussion

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Implication

Endogenous NO modulates renal vasoconstriction by NE and Ang II in dogs; leaves open translation to human physiology or therapy.

Structured PICO

Does NG-nitro-L-arginine enhance norepinephrine- and angiotensin II-induced renal vasoconstriction and antidiuresis in anesthetized dogs?

P
Population
Anesthetized dogs
I
Intervention
Intrarenal administration of a NO synthase inhibitor, NG-nitro-L-arginine (NOARG), at doses of 10 and 40 micrograms/kg/min during intrarenal arterial infusion of norepinephrine (100 ng/kg/min) or angiotensin II (10 ng/kg/min)
C
Comparator
Norepinephrine or angiotensin II infusion alone, and simultaneous administration of L-arginine (a NO precursor)
O
Outcome
Renal blood flow (RBF), glomerular filtration rate (GFR), and urine formationsurrogate

Endogenous nitric oxide likely functions as an inhibitory modulator in norepinephrine- or angiotensin II-induced renal vasoconstriction and antidiuresis.

Cite This Study

Matsumura et al. (1995) studied this question.

synapsesocial.com/papers/6a917ed3d613fa9f3b4667f8https://doi.org/10.1248/bpb.18.496
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Basally Synthesized Nitric Oxide in Modulating the Renal Vasoconstrictor Action of Angiotensin II.1997 · 8 citations
  2. 2Nitric oxide modulates angiotensin II- and norepinephrine-dependent vasoconstriction in rat kidney1996 · 66 citations
  3. 3Renoprotective effects of nitric oxide in angiotensin II-induced hypertension in the rat1998 · 74 citations
  4. 4Basal nitric oxide production curtails arteriolar vasoconstrictor responses to ANG II in rat kidney1996 · 51 citations
  5. 5Role of Nitric Oxide in Modulating the Long-term Renal and Hypertensive Actions of Norepinephrine1997 · 11 citations