June 1, 1993Hypertension

Role of nitric oxide in long-term angiotensin II-induced renal vasoconstriction.

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Population

8 unilaterally nephrectomized, conscious dogs

Comparison

Angiotensin II infusion into the renal artery at… vs Intra-subject comparison

Design

Preclinical

Follow-up

19 days (total protocol duration)

Authors

RMR. Davis ManningJackson Memorial Hospital LHLufei HuMerck & Co., Inc., Rahway, NJ, USA (United States)HMH. L. MizelleOrlando Regional Medical Center

Discussion

Member takes

Implication

Should not yet change practice; hypothesis-generating for Ang II–NO interactions in renal hemodynamics.

Structured PICO

Population

8 unilaterally nephrectomized, conscious dogs

Intervention

Angiotensin II (Ang II) infusion into the renal artery at 0.5 ng/kg per minute for 5 days, followed by intravenous NG-nitro-L-arginine-methyl ester (L-NAME) at 10 micrograms/kg per minute for 5 days, followed by combined Ang II and L-NAME for 5 days

Comparator

Intra-subject comparison (effects of Ang II alone vs. Ang II after L-NAME pretreatment)

Outcome

Renal plasma flow and glomerular filtration ratesurrogate

In a canine model, nitric oxide synthesis inhibition potentiates the long-term effects of angiotensin II on glomerular filtration rate but has only additive effects on renal plasma flow.

Cite This Study

Manning et al. (1993) studied this question.

synapsesocial.com/papers/6a86ae2fc026610cc182a5bf https://doi.org/10.1161/01.hyp.21.6.949

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Role of nitric oxide in long-term angiotensin II-induced renal vasoconstriction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of nitric oxide in long-term angiotensin II-induced renal vasoconstriction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider