Why the study?
Do nitric oxide and prostaglandins modulate the renal hemodynamic effects of angiotensin II in anaesthetized rats?
Population
Captopril-treated anaesthetized rats
Comparison
Intrarenal artery infusion of Angiotensin II… vs Angiotensin II infusion without pretreatment
Design
Preclinical
Authors
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Hypothesis-generating in anaesthetized rats; leaves open whether NO-Ang II interactions apply to human renal disease.
Do nitric oxide and prostaglandins modulate the renal hemodynamic effects of angiotensin II in anaesthetized rats?
Nitric oxide and cyclooxygenase-derived prostaglandins modulate the renal hemodynamic effects of angiotensin II, likely through complex interactions at the glomerulus.
Clayton et al. (1998) studied this question.
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