What does this research mean for the field?

Endogenous nitric oxide facilitates sympathetic norepinephrine release in the rat kidney through cGMP-independent mechanisms, while counteracting vasoconstriction via NO metabolites, without the contribution of neuronal nitric oxide synthase. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 2002AJP Regulatory Integrative and Comparative Physiology

Facilitatory role of NO in neural norepinephrine release in the rat kidney

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Structured PICO

Population

Isolated pump-perfused rat kidney

Intervention

Electrical renal nerve stimulation (1 and 2 Hz) combined with NOS inhibitors (L-NAME, N(omega)-nitro-L-arginine, 7-nitroindazole sodium salt), NO scavenger (carboxy-PTIO), or cGMP modulators

Comparator

Electrical renal nerve stimulation alone or with L-arginine pretreatment

Outcome

Renal norepinephrine (NE) efflux and renal perfusion pressuresurrogate

Endogenous NO facilitates norepinephrine release in the rat kidney through cGMP-independent mechanisms, without contribution from neuronal NOS.

Discussion

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Implication

Suggests NO facilitates renal NE release independently of nNOS/cGMP; hypothesis-generating for sympathetic control in human cardiorenal disease.

Cite This Study

Tanioka et al. (2002) studied this question.

synapsesocial.com/papers/6a1ec40bbf2a5d44faaf4ab0 https://doi.org/10.1152/ajpregu.00697.2001

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Implication

Suggests NO facilitates renal NE release independently of nNOS/cGMP; hypothesis-generating for sympathetic control in human cardiorenal disease.

Facilitatory role of NO in neural norepinephrine release in the rat kidney

Structured PICO

Discussion

Implication

Cite This Study

Facilitatory role of NO in neural norepinephrine release in the rat kidney

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider