Key result
Endogenous and exogenous nitric oxide inhibits norepinephrine release from sympathetic nerves in the rat heart.
Population
Rat hearts perfused in the Langendorff mode
Comparison
NO synthase inhibitors and NO-donor compounds vs Control conditions
Design
Preclinical
Authors
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Nitric oxide may inhibit cardiac sympathetic transmission in rats; leaves open translation to human autonomic regulation or therapy.
Endogenous and exogenous nitric oxide exert an inhibitory control on norepinephrine release from sympathetic nerves in the rat heart.
Schwarz et al. (1995) studied this question. Nitric oxide synthase inhibitors and NO donors was evaluated on Norepinephrine release from sympathetic nerves. Endogenous and exogenous nitric oxide inhibits norepinephrine release from sympathetic nerves in the rat heart.
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