Key result
Non-specific NOS inhibition with L-NMMA enhanced the bradykinin-induced pressor reflex (32 to 39 mmHg, P<0.05), whereas selective brain NOS inhibition with 7-NI reduced it (37 to 18 mmHg, P<0.05).
Population
Anesthetized, sinoaortic-denervated and vagotomized cats
Comparison
Nonspecific NO synthase inhibitor… vs Baseline response before inhibitor…
Design
Preclinical
Authors
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Animal data show isoform-specific NOS effects on cardiac reflexes; leaves open translation to human autonomic regulation.
p-value: p=<0.05
Neuronal NOS facilitates, whereas endothelial NOS modulates, the excitatory cardiovascular reflex elicited by chemical stimulation of sympathetic cardiac afferents.
Tjen‐A‐Looi et al. (2001) studied Anesthetized, sinoaortic-denervated and vagotomized cats. Nitric oxide synthase inhibitors (L-NMMA and 7-NI) vs. Baseline / Vehicle control was evaluated on Change in mean arterial pressure (MAP) in response to bradykinin (p=<0.05). Non-specific NOS inhibition with L-NMMA enhanced the bradykinin-induced pressor reflex (32 to 39 mmHg, P<0.05), whereas selective brain NOS inhibition with 7-NI reduced it (37 to 18 mmHg, P<0.05).
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