Why the study?
Does inhibition of NO synthesis potentiate dynamic sympathetic regulation of aortic pressure and heart rate in anesthetized rabbits?
Population
Anesthetized rabbits
Comparison
Inhibition of NO synthesis by… vs Control state
Design
Preclinical
Authors
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Indicates basal NO supports tonic but not dynamic baroreflex control in rabbits; leaves open translation to conscious or human physiology.
Does inhibition of NO synthesis potentiate dynamic sympathetic regulation of aortic pressure and heart rate in anesthetized rabbits?
Basal NO release contributes to tonic blood pressure regulation but does not appear to modulate dynamic sympathetic regulation of aortic pressure or heart rate via the baroreflex.
Miyano et al. (1997) studied this question.
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