Why the study?
Does nitric oxide modulation alter heart rate variability and baroreflex sensitivity in healthy human subjects?
Population
26 healthy male volunteers, mean age 23+/-5 years.
Comparison
Inhibition of endogenous NO production with… vs Equipressor dose of control vasoconstrictor…
Design
Other
Authors
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Supports NO augmentation of vagal control in humans; extends animal data but leaves clinical translation in disease open.
Does nitric oxide modulation alter heart rate variability and baroreflex sensitivity in healthy human subjects?
Nitric oxide augments cardiac vagal control in healthy humans, as evidenced by changes in heart rate variability and baroreflex sensitivity during NO inhibition and donation.
Chowdhary et al. (2000) studied this question.
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