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December 1, 1998Journal of Hypertension

Role of endogenous nitric oxide in the nucleus tratus solitarii on baroreflex control of heart rate in spontaneously hypertensive rats

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Population

Male age- and weight-matched spontaneously hypertensive and normotensive Wistar-Kyoto rats chronically…

Comparison

Infusion of NG-monomethyl-L-arginine and… vs Vehicle infusion (3 nl/min) into the NTS

Design

Preclinical

Authors

VPVera PontieriMVMaria Kelly VenezuelaCSCristóforo Scavone

Discussion

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Overview

Should not inform clinical hypertension care; hypothesis-generating for NTS nitric oxide in baroreflex impairment.

Structured PICO

P
Population
Male age- and weight-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats chronically instrumented with cannulas in the NTS, artery and vein
I
Intervention
Infusion of NG-monomethyl-L-arginine (L-NMMA) and L-arginine (L-Arg) into the nucleus tractus solitarii (NTS)
C
Comparator
Vehicle infusion (3 nl/min) into the NTS
O
Outcome
Basal pressure (AP), heart rate (HR) and reflex HR responses during loading/unloading of baroreceptorssurrogate

Endogenous nitric oxide in the NTS modulates baroreceptor reflex control of heart rate by increasing HR range, an effect that is depressed in spontaneously hypertensive rats due to lower NOS activity.

Cite This Study

Pontieri et al. (1998) studied this question.

synapsesocial.com/papers/6a8bd2460ca85c7e33df0f07https://doi.org/10.1097/00004872-199816121-00021
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