October 1, 1997AJP Heart and Circulatory Physiology

Endogenous nitric oxide on arterial hemodynamics: a comparison between normotensive and hypertensive rats

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Why the study?

Does nitric oxide blockade with L-NAME differentially affect arterial hemodynamics in spontaneously hypertensive rats compared to normotensive rats?

Population

Spontaneously hypertensive rats and normotensive Wistar-Kyoto strain, 22-26 weeks of age.

Comparison

N-nitro-L-arginine methyl ester administered… vs Normotensive Wistar-Kyoto rats and baseline…

Design

Preclinical

Authors

HCHsing I. ChenFu Jen Catholic University CHCheng HuAnhui University of Science and Technology

Discussion

Member takes

Implication

Supports enhanced endogenous NO effects on pressure and resistance in hypertensive models; leaves open human applicability.

Structured PICO

Does nitric oxide blockade with L-NAME differentially affect arterial hemodynamics in spontaneously hypertensive rats compared to normotensive rats?

Population

Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto strain (WKY), 22-26 weeks of age (n=12 WKY and n=12 SHR in the impedance spectral analysis series).

Intervention

N(G)-nitro-L-arginine methyl ester (L-NAME) administered intravenously (1-30 mg/kg i.v. for dose-response; 10 mg/kg i.v. for impedance spectral analysis).

Comparator

Normotensive Wistar-Kyoto (WKY) rats and baseline measurements prior to NO blockade.

Outcome

Changes in arterial pressure (AP), heart rate (HR), and total peripheral resistance (TPR).surrogate

Endogenous nitric oxide predominantly affects arterial pressure and peripheral resistance, with these effects being enhanced in rats with established hypertension.

Cite This Study

Chen et al. (1997) studied this question.

synapsesocial.com/papers/6a7d67a658b935a3e446df81 https://doi.org/10.1152/ajpheart.1997.273.4.h1816

Topics

Hypertension management

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Endogenous nitric oxide on arterial hemodynamics: a comparison between normotensive and hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Endogenous nitric oxide on arterial hemodynamics: a comparison between normotensive and hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider