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September 1, 1998Clinical and Experimental Pharmacology and Physiology

Effects of Nitric Oxide Synthase Inhibition and Endothelin Eta Receptor Blockade on Haemodynamics in Hypertensive Rats

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Population

Spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats

Comparison

NG-monomethyl-L-arginine 20 mg/kg or BQ 123 1… vs Normotensive Wistar-Kyoto rats and baseline…

Design

Preclinical

Authors

SGS‐O GranstamLLLars LindEGElisabet Granstam

Discussion

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Overview

Supports preserved NO basal tone in SHR vasculature; leaves open relevance to human hypertension.

Structured PICO

P
Population
Spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats
I
Intervention
NG-monomethyl-L-arginine (L-NMMA) 20 mg/kg or BQ 123 1 mg/kg, with subsequent acetylcholine (ACh) infusion (2 micrograms/kg per min)
C
Comparator
Normotensive Wistar-Kyoto (WKY) rats (strain comparison) and baseline hemodynamics
O
Outcome
Regional hemodynamics (blood pressure, cardiac index, and blood flow/vascular resistance in heart, kidney, and skeletal muscle)surrogate

The contribution of nitric oxide to basal vessel tone is not impaired in the heart, skeletal muscle, and kidney of spontaneously hypertensive rats.

Cite This Study

Granstam et al. (1998) studied this question.

synapsesocial.com/papers/6a20aee88e09200678d114dbhttps://doi.org/10.1111/j.1440-1681.1998.tb02278.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endogenous nitric oxide on arterial hemodynamics: a comparison between normotensive and hypertensive rats1997 · 44 citations
  2. 2Release of nitric oxide in response to acetylcholine is unaltered in spontaneously hypertensive rats1994 · 44 citations
  3. 3<b>Nitric Oxide In Mesenteric Vascular Reactivity: A Comparison Between Rats With Normotension And Hypertension</b>2002 · 43 citations
  4. 4Effects of chronic treatment with nitric oxide synthase inhibitors on regional haemodynamic responses to vasodilators in conscious Brattleboro rats1993 · 17 citations
  5. 5The role of nitric oxide in the regional vasodilator effects of endothelin‐1 in the rat1992 · 34 citations