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July 1, 1994Journal of Hypertension

Release of nitric oxide in response to acetylcholine is unaltered in spontaneously hypertensive rats

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Why the study?

Does acetylcholine stimulate nitric oxide release differently in spontaneously hypertensive rats compared to normotensive rats?

Population

Adult spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats

Comparison

Intravenous injection of 40 micrograms/kg… vs Vehicle administration before acetylcholine

Design

Preclinical

Authors

YSYoshie SawadaTSTetsuo SakamakiTNTetsuya Nakamura

Discussion

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Overview

Preserved acetylcholine-stimulated NO release in SHR models; hypothesis-generating for endothelial function in human hypertension and requires clinical validation.

Structured PICO

Does acetylcholine stimulate nitric oxide release differently in spontaneously hypertensive rats compared to normotensive rats?

P
Population
Adult spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats
I
Intervention
Intravenous injection of 40 micrograms/kg acetylcholine following administration of L-NAME (30 mg/kg) or its vehicle
C
Comparator
Vehicle administration before acetylcholine
O
Outcome
Mean arterial pressure and serum levels of nitrate and nitrite (NO metabolites)surrogate

The release of nitric oxide stimulated by acetylcholine is unaltered in spontaneously hypertensive rats, suggesting NO production in response to acetylcholine is preserved in this model.

Cite This Study

Sawada et al. (1994) studied this question.

synapsesocial.com/papers/6a7ac17d14b028facf0e88a2https://doi.org/10.1097/00004872-199407000-00004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Acetylcholine and Nitroprusside on Systemic and Regional Hemodynamics in Hypertensive Rats1998 · 14 citations
  2. 2EFFECTS OF NITRIC OXIDE SYNTHASE INHIBITION AND ENDOTHELIN ET<sub>A</sub> RECEPTOR BLOCKADE ON HAEMODYNAMICS IN HYPERTENSIVE RATS1998 · 8 citations
  3. 3Sulfhydryl group donors potentiate the hypotensive effect of acetylcholine in rats.1993 · 30 citations
  4. 4Higher level of plasma nitric oxide in spontaneously hypertensive rats1999 · 57 citations
  5. 5Hypertension and ageing impair acetylcholine-induced vasodilation in rats1994 · 56 citations