May 1, 1999American Journal of HypertensionOpen Access

Higher level of plasma nitric oxide in spontaneously hypertensive rats

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Population

Spontaneously hypertensive rats (SHR) and genetic normotensive controls, Wistar-Kyoto rats (WKY)

Comparison

Administration of endotoxin for 3 hours, and in… vs Normotensive WKY rats and untreated conditions

Design

Preclinical

Authors

CWC. C. WuChang Gung University

Discussion

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Implication

Supports compensatory NO in hypertensive rat models; hypothesis-generating and should not change practice.

Structured PICO

Population

Spontaneously hypertensive rats (SHR) and genetic normotensive controls, Wistar-Kyoto rats (WKY)

Intervention

Administration of endotoxin (lipopolysaccharide [LPS]) for 3 hours, and in vitro testing of thoracic aortae with acetylcholine (ACh) in the presence or absence of N(omega)-nitro-L-arginine methyl ester (L-NAME)

Comparator

Normotensive WKY rats and untreated conditions (without LPS or L-NAME)

Outcome

Nitrate levels in plasma and aorta, and vascular relaxation response to acetylcholinesurrogate

Elevated plasma nitric oxide levels in spontaneously hypertensive rats may result from NO release from dinitrosyl nonheme iron complexes in the vascular bed as a compensatory mechanism against hypertension.

Cite This Study

C. C. Wu (1999) studied this question.

synapsesocial.com/papers/6a82fe51ee90e576a3af8325 https://doi.org/10.1016/s0895-7061(99)00008-4

Topics

Hypertension management

View Full Paper

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Higher level of plasma nitric oxide in spontaneously hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Higher level of plasma nitric oxide in spontaneously hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider