Population
Middle cerebral arteries (MCA) from normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats
Comparison
Evaluation of nitric oxide pathway alterations… vs Normotensive Wistar-Kyoto (WKY) rats
Design
Preclinical
Authors
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Should not yet inform clinical hypertension management; leaves open iNOS upregulation as cerebrovascular research target.
In spontaneously hypertensive rats, endothelial NO production remains intact, but there is an upregulation of basal iNOS expression in cerebral arteries.
Briones et al. (2002) studied this question.
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