Population
Carotid artery rings without endothelium from spontaneously hypertensive rats and normotensive Wistar-Kyoto…
Comparison
Angiotensin II stimulation with or without NOS… vs Normotensive Wistar-Kyoto rats; basal conditions
Design
Preclinical
Authors
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Caution against clinical extrapolation; leaves open a VSMC nNOS pathway in hypertension for mechanistic validation.
Demonstrates the expression and Angiotensin II-mediated activation of neuronal NOS in vascular smooth muscle cells of spontaneously hypertensive rats, highlighting a potential nonendothelial mechanism in hypertension.
Boulanger et al. (1998) studied this question.
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