The L-arginine-NO pathway in the rostral ventrolateral medulla shows enhanced depressor responses to NO in spontaneously hypertensive rats, suggesting pathway impairment contributes to genetic hypertension.
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Greater L-arginine depressor effects in SHR models; leaves open whether RVLM NO pathway modulation merits human hypertension trials.
Kagiyama et al. (1998) studied this question.
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