Key result
High-dose local infusion of l- and d-arginine (160 μmol/min) caused a significant, non-stereospecific increase in venous diameter and forearm blood flow compared with control values.
Why the study?
Does local infusion of arginine increase venous diameter and forearm blood flow in healthy subjects?
Population
Healthy subjects
Comparison
Local infusion of l- and d-arginine free base… vs Control values
Design
Other
Authors
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Challenges NO pathway mediation assumptions for arginine vasodilation; leaves open clinical hypotensive applications and mechanistic studies.
Does local infusion of arginine increase venous diameter and forearm blood flow in healthy subjects?
High-dose arginine causes non-stereospecific peripheral vasodilation in humans, indicating its hypotensive effect is not solely mediated by the provision of excess substrate for the l-arginine/nitric oxide pathway.
Calver et al. (1991) studied Healthy subjects. l- and d-arginine vs. Control values was evaluated on Venous diameter and forearm blood flow. High-dose local infusion of l- and d-arginine (160 μmol/min) caused a significant, non-stereospecific increase in venous diameter and forearm blood flow compared with control values.
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