April 1, 1992AJP Heart and Circulatory Physiology
Endothelium-dependent dilation to L-arginine in isolated rat skeletal muscle arterioles
Why the study?
Does L-arginine induce endothelium-dependent dilation in isolated rat skeletal muscle arterioles?
Population
Isolated, pressurized first-order rat cremaster muscle arterioles (93 +/- 2.9 microns)
Comparison
L-arginine (10(-5)-10(-3) M) vs D-arginine (10-10 M), NG-nitro-L-arginine…
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Supports L-arginine–mediated endothelium-dependent dilation in rat skeletal muscle arterioles; leaves open translation to human microvascular regulation.
Structured PICO
Does L-arginine induce endothelium-dependent dilation in isolated rat skeletal muscle arterioles?
P
Population
Isolated, pressurized first-order rat cremaster muscle arterioles (93 +/- 2.9 microns)
I
Intervention
L-arginine (10(-5)-10(-3) M)
C
Comparator
D-arginine (10(-5)-10(-3) M), NG-nitro-L-arginine (L-NNA, 10(-3) M), and removal of the endothelium
O
Outcome
Arteriolar dilationsurrogate
L-arginine induces endothelium-dependent dilation in skeletal muscle arterioles, highlighting the role of endothelium-derived relaxing factor in regulating microvascular resistance.
Cite This Study
Sun et al. (1992) studied this question.