Population
Rat cremaster muscle (third-order arterioles)
Comparison
Topical application of endothelin-1 with or… vs Baseline or different antagonist conditions
Design
Preclinical
Authors
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No change to clinical vascular management; leaves open endothelin-1/NO crosstalk relevance in human resistance vessels.
Endothelin-1 causes arteriolar dilation by stimulating endogenous nitric oxide production, which attenuates its constrictor effects on small resistance vessels in striated muscle.
Zhao et al. (1998) studied this question.
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